Epistra and Evident Co-develop a New AI-powered Microscopy Experience

Launch of the Next-generation Confocal Laser Scanning Microscope FLUOVIEW FV5000 with AI-assisted Software FLUOVIEW Smart

Epistra Inc. and Evident Corporation jointly designed and developed an AI object search system that significantly reduces the effort required for microscope operation.

This system is incorporated into FLUOVIEW Smart, an AI-powered software that assists users with microscope operation. The next-generation confocal and multiphoton laser scanning microscope FLUOVIEW FV5000, equipped with this software, was launched by Evident on October 29, 2025.

Background and Objectives

Confocal laser scanning microscopes are fundamental tools in life science research, enabling high-resolution observation of fine structures in cells and tissues and their three-dimensional analysis.

In recent years, as research has become more sophisticated and observation techniques have advanced, confocal microscopes have gained increasingly diverse functions, greatly expanding the flexibility of imaging conditions. However, with this expansion of capabilities, software interfaces have become more complex, and challenges have emerged — particularly for novice users — such as time-consuming setup and operation and increased susceptibility to operational errors.

To address these challenges, both companies carried out joint development aimed at creating an environment where users of all experience levels can perform observations smoothly, through simplified software interfaces and the application of AI technology. By combining Epistra’s expertise in mathematical optimization and image analysis with Evident’s optical design technology, the AI-powered software FLUOVIEW Smart was created, enabling “anyone to acquire high-quality images quickly and intuitively.”

What is FLUOVIEW Smart?

FLUOVIEW Smart is an AI-assisted software built into Evident’s next-generation confocal laser scanning microscope FLUOVIEW FV5000. It was developed to optimize the user’s observation workflow and significantly streamline the entire process from imaging preparation to image acquisition.

The software uses AI to automatically detect the position and structure of specimens, accurately identify the observation target, and optimize laser power and imaging conditions. This enables the startup and adjustment process — which previously took several minutes — to be completed with a single click in under one minute. Novice users can obtain high-quality images without confusion, while experienced users benefit from improved work efficiency and enhanced reproducibility of imaging conditions.

Epistra developed the core AI object search system for FLUOVIEW Smart. This system automatically detects specimen regions from low-magnification images and supports the process of switching to high magnification for detailed imaging. This enables a workflow that delivers consistent observation results regardless of the user’s experience or skill level.

Additionally, this system incorporates Epistra’s proprietary condition optimization AI, Epistra Accelerate. This enables automatic optimization of imaging conditions such as laser power, allowing stable acquisition of high-quality images.

Born from the fusion of Epistra’s AI analysis technology and Evident’s optical technology, FLUOVIEW Smart transforms the confocal microscope operating experience into something more intuitive and seamless, proposing a new standard for research environments.

Related Links

• FLUOVIEW FV5000 Product Page (Evident Corporation)
• FLUOVIEW FV5000 Launch News Release (Evident Corporation)
• FLUOVIEW Smart White Paper (Evident Corporation)
• Epistra Accelerate Product Page (Epistra Inc.)

Company Information

About Evident Corporation

Evident has inherited over 100 years of optical technology cultivated as Olympus, establishing industry standards for optical precision in the microscopy field. Today, through advanced imaging solutions that combine superior optical technology with cutting-edge digital innovation, Evident supports researchers, medical professionals, and engineers in “visualizing the invisible.”

In the life sciences domain, Evident offers a diverse range of products including fluorescence imaging systems, AI image analysis, and digital pathology, broadly supporting research, clinical practice, and education. From elucidating biological phenomena to quality assurance, the company contributes to new discoveries and the creation of innovation.

About Epistra Inc.

Epistra is an AI solutions company that supports research and development in life science fields, including pharmaceutical companies. Leveraging its proprietary experimental condition optimization AI “Epistra Accelerate” and image analysis AI “Epistra Vision,” the company provides hands-on support services tailored to research environments. With over 60 implementations primarily at major pharmaceutical companies, Epistra achieved more than 80% improvement in differentiation efficiency of retinal pigment epithelial cells through collaborative research with RIKEN. The results have been published in the international journal “eLife.”

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FLUOVIEW and FLUOVIEW Smart are trademarks of Evident Corporation and its subsidiaries.